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Furthermore, unlike long-acting GLP-1 analogs that also signal through the incretin pathway, DPP-4 inhibitors do not require parenteral administration, and their long-term use is associated with a low risk of gastrointestinal adverse effects and no meaningful increases in heart rate [37,38,39,40]

10 Later that year, Zepbound received FDA approval to treat obstructive sleep apnea

Although much attention has focused on GLP1RAinduced delays in gastric emptying and gastroparesis, there remains a significant gap in studies examining the impact of small intestinal transit time on the absorption of oral medications